The U.S. Chamber of Commerce is ready to take on the tea party in 2014 Senate primaries and elections with a deep-pocketed boost of establishment and business Republican candidates.

“Our No. 1 focus is to make sure, when it comes to the Senate, that we have no loser candidates,” Chamber strategist Scott Reed told The Wall Street Journal. “That will be our mantra: No fools on our ticket.”

The financial support, which The Hill reported would pour at least $50 million into the campaigns of centrist GOP candidates, is part of an aggressive approach toward tea party Republicans since the 16-day October government shutdown.

The Chamber has expressed its displeasure with tea party favorites Sen. Ted Cruz of Texas and Sen. Mike Lee of Utah, who resisted passing a budget without a provision to defund Obamacare, triggering a stalemate.

Just a month later, the Chamber jumped into the intra-party GOP voting, backing establishment GOP candidate Bradley Byrne over tea party prospect Dean Young in an Alabama special House election.

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