House Minority Leader Nancy Pelosi, California Democrat, said Tuesday that a large segment of the GOP is “anti-government, anti-science and anti-Obama” and that while Democrats opposed much of President George W. Bush’s agenda, Republican obstruction to President Obama is “something quite stunning.”

“What’s interesting to me is that Democrats and Republicans know what they believe,” Mrs. Pelosi said on MSNBC’s “The Daily Rundown.” “They know what they believe, and that’s what’s happening in Congress … what’s happening here now is we have a large segment of the Republican party that is anti-government. We don’t want any more government than we need, but they’re anti-government, anti-science and anti-Obama.”

“They have a trifecta that is going,” she continued. “Now, I say to the Republicans: Take back your party … you come with confidence with the debate that goes on and try to influence the decision, but to obstruct every initiative that the president’s put forth on jobs and then say, ‘Why don’t we have more jobs?’ We do have more jobs, but no thanks to the Congress of the United States.”

Mrs. Pelosi argued that while Democrats opposed Mr. Bush on many issues, including the Iraq War and his efforts to privatize Social Security, they also worked together on many issues such as the Wall Street bailout and energy legislation.